One of the things Vanessa talks about is the relevance of PageRank. As Rand says in the interview, a lot of people are obsessed with their PageRank score. Basically Vanessas advice is don’t waste all your energy on ranking. Having a good rank will obviously be of benefit to you but if you spend all your energy on ranking, you’ll probably go blind.
This post should be read in a Jonathan Ross style for full effect.